The altarpiece is not only Mattia Preti’s first work in this church but also one of the most outstanding. It was commissioned by Grand Master Martin de Redin in 1659 and depicts St George riding a white stallion having just slain the dragon.

One of the most magnificent and richly embellished chapels in the church, the Chapel of the Langue of Aragon, is dedicated to St George, the patron saint of the Aragonese Knights. The langue of Aragon consisted of the Priory of Catalonia and that of Navarre.

The Lunettes on either side of the chapel are also works by Preti and show scenes from the life of St Lawrence.